Licensing

Overcoming Development Hurdles Through Partnerships

The average cost of a drug from development to commercialization is US$1 Billion. It takes on average ten (10) years for a new drug to reach the clinic. Only 1 in 10,000 of these drugs will make it on to the market.

With such a high rate of attrition, increase your likelihood of success, by moving one of our pipeline assets forward into the clinic.

Check out our list of candidates available for licensing below.

Licensing Opportunities

Check out the list of the current programs that are available for licensing.

Mechanism of Action. Small molecule ATP-competitive kinase inhibitor.

Description. A potential first in-class small molecule kinase inhibitor that targets transforming growth factor-beta (TGF-β) signaling pathway. The inhibitor can be used alone or with PD1/PD-L1 inhibitors to increase the efficacy of immune checkpoint inhibitors.

Therapeutic Area. Oncology

Stage of Development. in silico
Mechanism of Action. An allosteric small molecule kinase inhibitor that inhibits BCR-ABL1 by binding to a pocket outside of the ATP binding site.

Description. Drug resistance is the major challenge for targeted therapeutics such as kinase inhibitors. The acquired mutation on the ATP-binding site often weakens or eliminates the kinase inhibitor binding. The novel PS-0080 allosteric tyrosine kinase Inhibitor can overcome the ATP-binding site drug resistant mutations..

Therapeutic Area. Oncology

Stage of Development. in silico
Mechanism of Action. Small molecule kinase mutant-specific inhibitor.

Description. A small molecule kinase inhibitor that targets the drug resistant EGFR T790M mutant.

Therapeutic Area. Oncology

Stage of Development. in silico
Mechanism of Action. PS-0087 is a small molecule kinase inhibitor which inhibits three different kinases simultaneously.

Description. Multiple signaling pathways are often deregulated in many types of cancers. Selectively inhibiting multiple oncogenes with a single drug has significant advantages over drug combination approaches.

Therapeutic Area. Oncology

Stage of Development. in silico
Mechanism of Action. Small molecule protein-protein interaction inhibitor of SARS-CoV-2 spike protein and human ACE2. SARS-CoV-2 uses ACE2 as receptor for entry of human cells, therefore inhibitors of the spike protein to Ace2 binding are effective therapeutics to prevent the host cell entry of the virus. All the current therapeutics under development are biologics (soluble ACE2 or antibodies), Our small molecule inhibitor will have advantages over biologics.

Description. PS-2018 is the first small molecule inhibitor designed to inhibit the spike protein and ACE2 interaction. All other therapeutics under development are biologics such as soluble ACE2 or antibodies against either the spike protein or ACE2. Our small molecule approach is expected to have significant advantages over biologic candidates for safety, ease of administration, and cost-effectiveness.

Therapeutic Area. Infectious Diseases

Stage of Development. in silico
Mechanism of Action. Small molecule inhibitor of SARS-CoV-2 serine protease, TMPRSS2.

Description.Although some protease inhibiting drugs such as camostat and nafamostat have been repurposed as TMPRSS2 inhibitors, their efficacy and selectivity are not ideal. Thus, there is a desperate need for specific and potent TMPRSS2 inhibitors.

Therapeutic Area. Infectious Diseases

Stage of Development. in silico

Latest News.

Press Release: How Local Biotech Company Leverages its Deep Learning Platform to Identify Drugs to Treat COVID

Anthony Marotta3 November 20203 min read
Press Release: How Local Biotech Company Leverages its Deep Learning Platform to Identify Drugs to Treat COVID

VANCOUVER, November 3, 2020 / Pharmasilico, the AI-based drug discovery company, is pleased to announce that they have leveraged their proprietary AI platform to identify 22 candidate drugs that could be effective in combating the current global COVID-19 pandemic. Twelve…

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